Psa density md calc

psa density md calc

Pointing at Ito cell, from structure to function or Cinderella story in liver histology Adriana Grigoras, Simona Eliza Giusca, Elena Roxana Avadanei, Cornelia Amalinei, Irina-Draga Caruntu For more than years, the hepatic stellate cells also known as Ito cells have been the object of numerous studies that aimed at their characterization both in normal and postlesional status, where they play a key role in fibrosis progression specific for chronic hepatic pathology.

Converged studies on their histophysiology have revealed other functions, namely the involvement in liver embryological development and regeneration, metabolisms regulation, modulation of local inflammatory and immune reactions. Ito cells plasticity is surprising, as they are able to provide the connection between the complex sinusoidal and parenchymal microenvironment, influencing by autocrine and paracrine mechanisms the extracellular matrix content in tight correlation to growth and repair necessities.

Last but not least, Ito cells take an active part in systemic homeostasis maintenance by their capacity to store and mobilize vitamin A, respectively. The evolving interest in their research will be undoubtedly followed by a better knowledge of the physiopathological sequences responsible for liver diseases, as new targets for the development of new therapeutic approaches directed toward improvement of prognosis and patients quality of life.

The utility of bone remodeling markers in the diagnosis, evolution and treatment response evaluation in bone metastases Mihail-Lazar Mioc, Horia George Haragus, Andrei Dan Balanescu, Pompiliu Horatiu Petrescu, Mihaela Iacob, Radu Prejbeanu After the lungs and liver, the bone is the third most common site for metastatic disease, appearing frequently in breast and prostate malignancies.

These pathological bone events that occur during psa density md calc evolution of the metastatic disease are usually the onset of osteolysis and they lower the patient s life quality, and are sometimes the cause of death due to the required treatments surgery, radiotherapy.

Due to the nature of the bone remodeling process, the markers that control bone resorption are the main early indicators of bone malignancy. Analyzing these indicators in conjunction with traditional tumoral markers such as the prostate specific antigen PSA and the type I collagen cross-linked telopeptide ICTP can often increase the sensibility of the investigation and the chances of diagnosing bone metastases.

The studies that were carried out in order to research this area of knowledge have had good ce e cancerul de prostata psa density md calc results. Most of the efforts are now medicamente în vietnam pentru prostatita into developing a better therapeutic strategy that would allow for the early diagnosis and treatment of the pathological bone events.

Until these markers can be used as standard investigation methods in all of our patients, some controlled studies must be carried out in order to statistically prove these results, which are purely observational.

Narrow band imaging endoscopy for detection of precancerous lesions of upper gastrointestinal tract Dan Nicolae Florescu, Elena Tatiana Ivan, Adriana Mihaela Ciocalteu, Ioana Andreea Gheonea, Diana Rodica Tudorascu, Tudorel Ciurea, Dan Ionut Gheonea Gastric cancer GC is an important health problem despite the advances in surgery and chemotherapy and although the incidence is decreasing, GC is still considered the second most common cause of deceases produced by cancer.

Survival rates in gastric cancer are low, mainly because most patients are often diagnosed in late stages. The current interest in the diagnostic of GC is the detection of early gastric cancer. Advances in high-resolution endoscopic techniques such as narrow band imaging NBI allow the detection of early precancerous lesions like polyps or metaplastic mucosa.

Performing only white light imaging endoscopy in order to detect gastric cancer can lead to omission or misdiagnose of a considerable number of early gastric iubitorii de baie cu prostatita. NBI endoscopy associated with other high-resolution examinations is viable in detecting early gastric cancer, though few studies also indicate that the endoscopist s expertise plays an important factor as well.

Histopathological aspects in autoimmune cutaneous manifestations associated with hepatitis C virus infection Laura Statescu, Dan Vata, Delia Ciobanu, Laura Gheuca Solovastru, Maria Rotaru Autoimmunity is characterized by activation of the immune system that attacks and destroys wrongly, the body s own structures.

All body tissues can be affected erythrocytes, leukocytes, platelets, blood vessels, muscle tissue, endocrine system, and otherincluding the skin. Autoimmune diseases have an increased frequency in women, especially in adulthood, and they are associated with hereditary factors. Although the etiology of autoimmune diseases is incompletely elucidated, there is an association between chronic infection with hepatitis C and autoimmunity, association highlighted and well documented in clinical studies.

Other viral infections do not have the same connotation in psa density md calc context of autoimmunity, but it is recognized that they are an important triggering factor in the pathophysiological mechanism. The cases associating chronic hepatitis C treated with interferon and ribavirin, with multiple autoimmune diseases substrate, raising the discussion of a possible pathophysiological correlation between them.

In the last 40 years, there was observed a rapid increase of their incidence, because of the UV radiations exposure and weather changes. Although its morbidity is a relatively modest one, the direct social costs of NMSCs are quite substantial due to a high incidence. Due to these reasons, numerous studies try to clarify psa density md calc etiopathogenic mechanisms of NMSCs, to elaborate treatment and prevention measures.

vaginoza si prostatita operație de prostată

In the last years, a special attention was given to the relation between inflammation and skin cancer. In our study, we performed a histological and immunohistological evaluation of the inflammatory reaction on a number of 73 surgical exeresis pieces coming from the patients diagnosed with NMSCs.

The peritumoral inflammatory reaction in NMSCs was an extremely variable one in intensity and distribution, from one case to another and even from one area to another within the same tumor, thus proving the complexity of the relations between tumor cells and the cells of the immune system. By comparing the intensity of the inflammatory reaction between the two main types of NMSCs, there was observed that in SCCs the inflammatory reaction was more intense in comparison to BCCs.

hrana interzisa pentru prostatita masaj simptome de prostatită

Also, in SCC there was highlighted a more abundant inflammatory psa density md calc in poorly differentiated carcinomas, in comparison to the well-differentiated ones. The presence of the immune system cells T-lymphocytes, macrophages, mast cells cirugia de prostata robotica the tumoral cells, in a direct contact with these, makes us believe that between the two categories of cells there may appear mechanisms of intercellular communication, distinct from the mechanisms of paracrine signaling.

Caspase 3 expression and plasma level of Fas ligand as apoptosis biomarkers in inflammatory endotoxemic lung injury Raluca-Stefania Fodor, Anca-Meda Georgescu, Bianca-Liana Grigorescu, Adrian-Dan Cioc, Mihaly Veres, Ovidiu-Simion Cotoi, Pal Fodor, Sanda-Maria Copotoiu, Leonard Azamfirei Objective: The objective of this study is to evaluate if the immunohistochemical expression of a pulmonary apoptosis marker and plasma level of Fas ligand FasL correlates with the dose- and time-dependent severity of lung injury, induced by the administration of lipo-polysaccharide LPS in an endotoxemic rat model.

postul tratează prostatita prostatita cu roxitromicină

We measured FasL plasma levels of the rats at different time points and analyzed the relationships with markers of lung injury. To investigate the level of caspase 3-protein expression, the immunohistochemistry of the lung tissue was assessed.

Archive issue

The prognostic and clinical significance of neuroimagistic and neurobiological vulnerability markers in correlation with the molecular pharmacogenetic testing in psychoses and ultra high-risk categories Laura Alexandra Nussbaum, Lavinia Maria Hogea, Nicoleta Ioana Andreescu, Raluca Claudia Gradinaru, Maria Puiu, Andrei Todica We approach an integrated, multidisciplinary, innovative research-action model in children and adolescents with psychosis and ultra high-risk categories.

Our main focus was: to investigate the psa density md calc and clinical significance of neuroimagistic and neurobiological vulnerability markers in correlation with the molecular pharmacogenetic testing in psychoses and ultra high-risk categories; the dynamic evaluation of the clinical evolution for the studied groups in correlation with specific neurobiological and neuroimagistic variables and markers.

Our research was conducted in the period on 87 patients, children and adolescents with psychosis 42 took treatment after pharmacogenetic testing, 45 without and 65 children with ultra high-risk UHR for psychosis - 32 benefited of pharmacotherapy after pharmacogenetic testing and 33 without. Also, the patients were evaluated through magnetic resonance MR spectroscopy at baseline and after pharmacotherapy. Our results, showed statistically significant differences of the clinical scores between the studied groups.

Our research was a proof, sustaining the use of the pharmacogenetic testing in clinical practice and the value of investigating relevant neurobiological and neuroimagistic markers for a personalized, tailored therapy for psychotic patients and neuro-psychiatric UHR categories, as a fruitful pathway of intervention and care. Corresponding author: Lavinia Maria Hogea; e-mail: laviniahogea yahoo.

Afterwards, their tissue distribution was established: white and brown adipose tissue, central nervous system, myocardium atrial and ventricularblood vessels, smooth gastrointestinal muscles stomach, small intestine, colongallbladder, urinary bladder, prostate, skeletal muscles.

Non-clinical trials have demonstrated the major implication of beta3-ARs in glucose metabolism, implicitly, in insulin release, and also in obesity. After 14 days of treatment, glycemia and enzymes involved in homeostasis of glucose metabolism, glucosephosphate dehydrogenase G6PDglucosephosphatase G6Pase and hexokinase were determined.

Results and Conclusions: Glycemia in animals treated with the tested compounds decreased statistically significant for groups C2 and C3 C2 was also the compound to favorably modify the dynamics of determined enzymes, together with the display of very good safety profile supported by minor, non-significant, histopathological changes. We aimed to identify the optimum morphological characteristics that best describe a polyp and convert them into feature vectors used for automatic detection of polyps present in images acquired by wireless capsule endoscopy WCE.

We prospectively psa density md calc 54 patients with clinical indications for WCE. Initially, physicians analyzed all images acquired, identifying the frames that contained small bowel polyps. Subsequently, all images were analyzed using an automated computer-aided diagnostic system designed and implemented to convert physical characteristics into vectors of numeric values.

The data set was completed with texture and color information, and then analyzed by a feed forward back propagation artificial neural network ANN trained to identify the presence of polyps in WCE frames. Overall, the neural network had In comparison, physicians diagnosis indicated Computer-aided diagnostic of small bowel polyps, based on morphological features detection methods, emulation and neural networks classification, seems efficient, fast and reliable for physicians.

Lectin purification from carp roe Cyprinus carpio L. That allowed obtaining lectin with electrophoretic purity provoacă prostatită micoplasmoză yielding of cca. The resulting lectin was thermostable, withstanding heating to 75 degrees C for 15 minutes, without noticeable loss of hemagglutinating activity.

CCRA showed the best agglutination titer with pigeon erythrocytes, weaker - with rabbit and dog erythrocytes, and significantly weaker - with human and rat erythrocytes. The best lectin activity inhibition possessed alkaline phosphatase of calf intestine and fetuin.

A comparative study on the histochemical specificity of CCRA and PHA-E using specimens of normal tissues, and that of colon neoplasia, showed similar, yet not identical binding properties. CCRA lectin rather differentially labeled adenoma and adenocarcinoma of colon, which psa density md calc its prospective applicability in diagnostic histopathology.

Morphological, imaging and surgical aspects in endometrial endometrioid adenocarcinoma Costin Berceanu, Alex Emilian Stepan, Claudia Mehedintu, Monica Mihaela Cirstoiu, Razvan Ciortea, Sabina Berceanu, Ioana Andreea Gheonea, Elvira Bratila Endometrioid endometrial adenocarcinomas EECs are frequent genital tumors for which the clinical, imaging and histopathological integrated analysis is the basis of differential diagnosis and therapeutic attitude.

This research represents a tertiary multicenter study including 58 cases examined histopathologically and immunohistochemically, surgically treated, on a five years period. The main characteristics of the patients in the study group are represented by the average age of 66 years, associated with obesity, hypertension, diabetes, history of infertility, early menopause, nulliparity or long-time oral contraception.

The most important clinical sign was the menopausal or postmenopausal vaginal bleeding. The golden standard in the diagnosis of endometrial carcinoma is the dilation and curettage of the uterine psa density md calc, din prostatită by histopathological assessment. The interrelation between the accurate histopathological diagnosis and the adequate surgical staging is the cornerstone of curative therapy in the EEC.

Incriminated etiological factors include antihypertensive, antiepileptic and immunosuppressant medication.

Develop your know-how on power solutions

We aimed to evaluate the induction of gingival overgrowth on experimental rats, depending on the drug type, dose and duration. In the research conducted by us, the increase in gingival tissue production occurred gradually, depending on the administered medication and the time elapsed after its start. The study conducted shows that experimentally induced gingival overgrowth of the administered drugs is made possible by altering tissue homeostasis through altering the fibrocyte cell populations involved in the tissular turnover as well as those involved milta pentru prostatita the inflammatory process.

A better understanding of the pathogenesis of this undesirable effect may lead to the development of improved management strategies for preventing it, or reducing it through non-surgical methods. Correlations between etiological factors and lesion severity in carotid artery atheromatosis Cristian Constantin, Dana-Maria Albulescu, Valeria-Carmen Albu, Aniela Raluca Danciu, Andrei-Constantin Deaconu Occurrence of atheromatous plaques on the internal wall of large and medium sized arteries represents a widely spread disease.

It is especially found in the elderly, but also in individuals belonging to the 4th-6th decade of life with an increasing incidence. Correlating the main etiological factors with morphological change severity, in conjunction with settling the psa density md calc of each factor on its own in generating and developing arterial plaques, has an important predictive role in the evolution of atherosclerotic pathology.

The purpose of this study is to investigate the existence of a correlation between the main factors linked to atheromatosis and the degree of severity of the carotid artery stenosis. This is obtained by ultrasonographic examination of the carotid arteries in correlation with determining serum cholesterol levels, thus ascertaining the risk for atheroma related events and disease progression. Poisoning caused psa analiza krvi these toxins is associated with acute and chronic liver damage.

Tussilago farfara coltsfootPetasites hybridus common butterburSenecio vernalis eastern groundsel and Symphytum officinale comfrey are traditional phytotherapic species, which beside the therapeutic bioactive compounds contain PAs. The aim of the paper was to assess the safety of some dry extracts obtained from these species. For the subacute toxicity testing, no death or any signs of toxicity were observed. Also, no significant differences in biochemical parameters were observed between control and treated groups.

The observed histopathological lesions were non-specific and were not consistent with the data reported in the literature for PAs exposure. In conclusion, the administration for 28 days, of the tested extracts, in a dose which correspond to a PAs concentration over the limits imposed in some countries, produced no hepatic and biliary toxic effects.

Further studies, extended over a longer period of time, are needed in order to determine the safety of plant extracts containing PAs. The fact that tumor growth is dependent on angiogenesis has supported researches for new prognostic parameters and the development psa density md calc novel therapeutic strategies.

Accordingly, we sought to evaluate angiogenesis quantitatively by assessing microvessel density in colorectal cancer.

Then, we aimed at comparing the performance of three endothelial cell markers CD31, CD34, and CD on formalin-fixed tissues from 58 patients diagnosed with colorectal cancer. Results: Following the comparison of the average effective vessels marked with the three markers, Student s t-test showed that the mean number of blood vessels marked with CD34 is higher than the blood vessels marked with CD31 and CD Clinical, immunological and pathological profile of infants suffering from cow s milk protein allergy Elena Tataranu, Smaranda Diaconescu, Camelia Geanina Ivanescu, Psa density md calc Sarbu, Maria Stamatin Cow s milk protein allergy CMPA is the most frequently encountered form of psa density md calc allergy in pediatric patients and occurs secondary to cow s milk proteins CMP ingestion.

The aim of this study is to define the profile of children suffering from CMPA and to describe the associated pathological findings. The authors performed a retrospective case-control study on infants that presented with CMPA symptoms at Sf. Fifty-five infants were diagnosed with CMPA Group 1 - cases group and had no proven allergy Group 2 - control group. Mean age of patients, gender distribution and prevalence of premature birth registered no statistically significant difference between the two groups.

The prevalence of familial history of allergy was higher in case of patients with CMPA CMPA usually manifested through an association of gastrointestinal The cadherin switch consists in the alteration of E-cadherin and N-cadherin expression and is specific for the EMT process. Materials and Methods: This study included 35 cases of primitive urothelial carcinomas investigated in relation with clinicopathological prognostic parameters and expression of E- and N-cadherins in psa density md calc advancing edge and intratumoral compartments.

Results: In both compartments, the immunoexpression of E-cadherin decreased, while that of N-cadherin increased in high grade, deeply invasive, or those cases with lymph node metastases and advanced stages carcinomas, with a negative linear correlation observed between their expression percentage values.

Primary retroperitoneal seminoma - embryology, histopathology and treatment particularities Constantin Virgil Gingu, Mihaela Mihai, Catalin Baston, Mugurel Alexandru Crasneanu, Alexandru Vladimir Dick, Vlad Olaru, Ioanel Sinescu in urothelial carcinomas, the variation of the two proteins immunostaining patterns being higher at the advancing edge.

The presence of N-cadherin in intratumoral compartment designated it as actively involved in EMT process. Conclusions: The analysis of cadherins switch can psa density md calc used to identify superficial urothelial carcinoma with invasion and metastasis potential.

Histological assessment of fracture healing after reduction of the rat femur using two different osteosynthesis methods Tiberiu Paul Neagu, Mirela Tiglis, Cristiana Gabriela Popp, Cristian Radu Jecan Osteosynthesis using Kirschner K wires and plates with screws were compared on the same subject in a previous experimental protocol, but none of them led to fracture healing.

We designed a new murine study in order to compare this two methods on different subjects in order to obtain histological proofs of which one is better and to see how limited periosteum removal influence fracture healing.

Divided in two equal groups, femoral osteotomies were performed on 30 Brown Norway rats, then reduced using plates and screws in the OPS osteosynthesis using plates and screws group and using K-wires in the OIKW osteosynthesis using Kirschner wire group. The animals underwent clinical, radiological and histological assessment for eight weeks. In conclusion, limited periosteum removal did not influence negatively fracture healing. Therefore, we considered that osteosynthesis using plates and screws led to better results compared to fracture fixation using K-wires.

Mai multe despre acest subiect